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00:00:03of
00:00:09You're watching TRT World, I'm Yashini Pariachi with the reminder of our
00:00:13main headlines. Iran's foreign minister says Terran and Oman
00:00:17are very close to deal a new shipping route through the straight of Hormus
00:00:21with technical and legal issues largely resolved. Iran's
00:00:25revolutionary guard has issued a stark warning though, saying Tehran can
00:00:29allow traffic to pass through if the US accepts all of Iran's
00:00:32conditions such as lifting the blockade of its
00:00:35ports. The reopening
00:00:38of the straight of hormos is in fact subject to
00:00:41in conditions said by the Islamic Republic of Iran and the
00:00:45straight will be reopened on the basis of those
00:00:48me conditions, that depends on the extent to which the United States
00:00:51accepts the conditions determined by the Islamic Republic of
00:00:55Iran. Turkey, Saudi Arabia and
00:00:58Pakistan have sign the landmark defense pact in Mecca, pledging
00:01:02attack on one will be treated as an attack on all. The Turkish
00:01:06President says the deal
00:01:08of reaffirms the right to
00:01:09a self-defense and is not aimed any country. The deal comes as
00:01:13tensions have grown across the region since the war
00:01:15started. Russian overnight strikes on Ukraine's
00:01:19keive region have killed three people, including
00:01:22of a child. Three others were injured when multiple locations just
00:01:25outside the capital were also hit. This comes as presidents.
00:01:30is in Belgrade on his first official visit to Serbia, one
00:01:33of the few countries that have maintained friendly relations with
00:01:36Russia. We have now reached an
00:01:40agreement with Trump that will grant the licenses, but just imagine if we had received
00:01:44them four years ago, we would already be manufacturing patriots for
00:01:47everyone, believe me, and Europe, the parts of Europe that
00:01:51want and would like to have patriots, anti-ballistic systems and
00:01:54missiles would already have them all. I'm absolutely certain of
00:01:58that. Authorities say fire at the
00:02:02Ilskiy oil refinery in Russia's southern
00:02:04of Krasnador region has been extinguished. Russia's defense ministry
00:02:08said
00:02:09of its air defenses destroy 397 Ukrainian
00:02:12drones over multiple regions
00:02:14overnight. And typhoon Dolphin is moving
00:02:18towards China with the sustained wind speed of 162
00:02:22km
00:02:22a an hour. It's already triggered heavy rains in
00:02:25of northern me Taiwan and passed close to southern Japan where it
00:02:28injured five people. and also caused a large scale
00:02:32blackout. The news continues here on TRT
00:02:36World, be sure to stay with
00:02:37us.
00:02:48of
00:02:53Most of us don't really
00:02:54of understand what goes on inside of our bodies until
00:02:58something goes wrong. bad knee, a hip that
00:03:01a goes out, tissue that doesn't heal properly, and for
00:03:05decades the answer was simple: manage it,
00:03:09operate on it, and hope for the best,
00:03:12of but now there's a new idea that's taking hold that the body
00:03:16doesn't need just fixing, that it might actually possess the tools to fix
00:03:20itself. what used to be science fiction is now a
00:03:23reality?
00:03:36in
00:03:49Stem a cells: you've probably heard the term being thrown
00:03:53around, in headlines,
00:03:55of in wellness clinics, maybe even
00:03:57in a conversation
00:03:58of with a friend who's... by their medical benefits.
00:04:02a report that doctor has found a way to grow a new wind pipe for
00:04:06patients with cancer. the first human trials of embryonic stem
00:04:10cells are now underway. a brand new law in tennessee
00:04:13of is
00:04:13of expanding the use of stem cells for medical treatment. we're back now with the
00:04:17controversy over stem cell clinics, but the truth
00:04:21is very few actually understand what they are,
00:04:24or why scientists consider them one
00:04:27of of the most significant frontiers. in modern
00:04:30medicine. Here's the simple version. Every
00:04:34organ in our body is built from billions of specialized
00:04:38cells. Skin cells repair our skin, muscle
00:04:42cells help us move, nerve cells carry signals throughout
00:04:46the body. But stem cells are different. They are
00:04:49found early embryos and naturally throughout
00:04:52of our bodies,
00:04:54me including in in bone marrow, blood and fat tissue. They
00:04:57can also be collected from umbilical... cored blood and cored tissue
00:05:01after birth. Unlike ordinary cells,
00:05:05stem cells haven't yet committed to becoming a specific
00:05:09cell type. They have the remarkable ability to... develop into
00:05:13many different types of cells, making them one the body's
00:05:17most versatile building blocks. when injury or
00:05:20disease damages tissue, stem cells can travel to the
00:05:24affected area, helping support the body's natural repair
00:05:28process. scientists are now learning how to
00:05:31isolate, grow and return these cells to patients in an
00:05:35effort to improve healing and recovery. today,
00:05:39stem cell therapies are already being used to treat. certain blood
00:05:43disorders, while researchers are studying their potential in areas
00:05:46ranging from orthopedics and neurology to optalmology and
00:05:50regenerative medicine. But successful stem cell
00:05:54therapy requires much more than science. It
00:05:58depends on an entire ecosystem of researchers,
00:06:01laboratories, hospitals, biobanks and
00:06:04regulators working together, and that's exactly the
00:06:08system Turkia is now trying to build.
00:06:13that entire chain, research, regulation,
00:06:16collaboration has to start somewhere in Turkey,
00:06:20one the places it starts is here at Onkim, this
00:06:24research center operates at the foundation of this
00:06:27ecosystem, but before a single treatment can happen,
00:06:31someone has to know exactly what they're dealing with at the cellular
00:06:35level, and that diagnostic work is where onkim has built
00:06:39its name,
00:07:13how you can balance
00:07:17business sustainability
00:07:20and
00:07:31the most important factor
00:07:33in ensuring sustainability is creating real value for
00:07:37people as
00:07:38in
00:07:43benefits, sustainability follows naturally.
00:07:47At Onkim, our focus is not soly financial. We place people at
00:07:51the center of everything we do. Our goal is to generate
00:07:55positive outcomes for patients while delivering those benefits in
00:07:59the most cost-effective way possible. In the past,
00:08:03many advanced molecular diagnostics and precision medicine
00:08:06services in Turkia relied heavily on overseas
00:08:10providers because domestic capability. were limited, as
00:08:14result, costs were significantly higher.
00:08:17today, by carrying out these services within our own company
00:08:21and within our own country, we're creating opportunities not
00:08:25only at the regional level, but also a global
00:08:29scale. of course, success requires more than the efforts of a single
00:08:33company, strong collaboration between the private sector and
00:08:36government is essential. innovation must be supported
00:08:40by timely and effective.
00:08:52and stem cell technology only means something if it can actually deliver precision treatment
00:08:56patient by patient. wanted to see how that promise
00:09:00holds up in the lab, because before a doctor can choose a
00:09:04treatment, something has to happen first, someone has to
00:09:08decode what's actually going wrong at the cellular level.
00:09:12this is: where modern medicine starts to look less like a
00:09:15playbook and more like fingerprint.
00:09:18increasingly treatment isn't built for disease, it's built for
00:09:22a specific patient down to the molecular detail their
00:09:26condition. that requires advanced genetic
00:09:29testing. to understand how that actually works, i spoke
00:09:33to punard, onkim's director.
00:09:37advanced diagnostic methods, particularly molecular and
00:09:41genetic testing, reached a very different level, especially in the field
00:09:45of cancer. Today, cancers and tumors are no
00:09:49longer analyzed solly based on their structural or standard
00:09:52pathological characteristics. We now conduct a wide
00:09:56range of analyses related to the molecular and genetic
00:09:59makeup of cancers and tumors. Not long
00:10:03ago, many patients with the same type of cancer received
00:10:07exactly the same treatment, but doctors often saw
00:10:11very different results. Today, scientists
00:10:15know that the two patients with the same cancer can have very different
00:10:19genetic mutations driving their disease, using
00:10:22advanced genetic and molecular test. laboratories can
00:10:26identify those mutations and build
00:10:29a detailed profile of each patient's cancer.
00:10:33That information helps doctors choose therapies that are more closely matched
00:10:37to each individual patient rather than relying a
00:10:41one size fits all approach. The result can be
00:10:45faster treatment, fewer side effects and a greater chance
00:10:48of success. It's a shift that's transforming how
00:10:52diseases like cancer are diagnosed. and
00:10:55treated, since we are no longer
00:10:58focusing only on the pathological characteristics of cancer,
00:11:02but to also its molecular features, we have made substantial
00:11:06progress in treatment, it has allowed cancer therapy to become
00:11:10much more personalized. can you talk to a little bit about what
00:11:14type of technologies and platforms are at the core
00:11:18of this lab?
00:11:22when onkim stemcell technologies was founded in
00:11:252005, it was established as a GMP laboratory
00:11:29focused soy on cold blood banking. Over the years, however,
00:11:33stemcell technologies experienced significant global
00:11:36advances. As onkim evolved, we expanded beyond cold
00:11:40blood banking to include the banking of stem cells obtained from
00:11:43various tissues as well as their production and delivery to patients
00:11:47whenever needed. We therefore collaborate closely with a wide
00:11:51range of medical specialties, hospitals and physicians.
00:12:03or you went under the knife of a surgeon, but what if healing
00:12:06didn't require going to a pharmacy or the hands of a
00:12:10surgeon?
00:12:11what if healing came from within if we could activate the cells
00:12:15that knew exactly what to fix? that
00:12:19idea healing from within has a name
00:12:23regenerative medicine and and it represents
00:12:26genuine shift in how we think about treatment, instead of
00:12:30only managing symptoms or replacing damaged tissue,
00:12:34the goal is to restore the body's own ability to repair
00:12:38itself. stem cells matter most precisely
00:12:42in that gap, in injuries and conditions where
00:12:45conventional treatment hits the ceiling, where surgery carries
00:12:49real risk or where the body simply needs support
00:12:53to do what it was already. built to do, that's the exact
00:12:57territory greentech was built to operate in,
00:13:00founded with focus on stem cell therapies and joint health, the
00:13:04company has since expanded its ambitions
00:13:07considerably. when we say regenerative medicine, we doesn't mean that
00:13:11we have to ignore or we have to get rid the medicine itself, because the medicine itself
00:13:15is something that we cannot, it's indispensable in our in our
00:13:19our life, because basically we have some treat some diseases like chronic
00:13:23diseases or some other diseases that we need to do a surger or operation for that,
00:13:27however regenerative medicines is kind of based or we focus on that
00:13:31regenerative medicine when we want to use we want to preserve
00:13:34or we want to just decrease the progression the disease itself, or for
00:13:38example we want to use it or think about it with patients that
00:13:42cannot be cannot enter to the or itself, for
00:13:45example older people or children or pregnant woman
00:13:49for example, that's why we try to go to the regenerative medicine and specifically in
00:13:53the athletes or sports medicine for. for example, me, for example, i would
00:13:57never like to have a surgery in my age, especially in the osteoarthritis level
00:14:01or any orthopedic level, that's why we try to go to the orthopedic or to
00:14:04the regenerative medicine field, like can do stem cell therapy, can do
00:14:08maybe PRP, which is at the beginning, what we can do as regenerative
00:14:12medicine to avoid and escape as much as possible from the
00:14:16or which is the surgery. i think you're talking about endless
00:14:19possibilities, i think one the first things that comes to mind and probably
00:14:23one the biggest concerns. in biotech in
00:14:27general is uh regulation and
00:14:30trust, yes, how do you balance
00:14:33innovation with patient safety?
00:14:37most most the challenging topics to be honest in our work, but we try to basically
00:14:41move with the science, so our main base and our main rule is to go and follow
00:14:45up the science first. for example, let's let me give you an example, when we talk about
00:14:49stem cells, so we need to to know all the information about stem
00:14:53cells and the scientific background about stem. cells and how can we use them medically over
00:14:57the humans over the human first and then accordingly think
00:15:01and see how can we apply them and we like because the regulatory part is really
00:15:04important some of so many like we have so many possibilities or
00:15:08treatments that we can use them and they can be logical however they are unethical
00:15:12or we cannot ethically use them over human that's why we try to focus more in
00:15:16the see the possibility these medicines or this options
00:15:20if we can do them over humans and accordingly and go over the
00:15:23treatment. Every breakthrough in medicine
00:15:27begins with research, but very few ever become
00:15:31actual products doctors can use a real
00:15:34patient. That gap between discovery. in
00:15:37delivery is far less forgiving than in most other
00:15:41industries. turning laboratory inside into something
00:15:45deployable takes more than good science. takes
00:15:48infrastructure, partnerships and people whose entire
00:15:52job is closing the distance. actually
00:15:55it is not easy to produce the real products
00:15:59from the lab to market,
00:16:02but therefore we get some help from
00:16:06the industry. therefore we uh talking about
00:16:09the green tech biotechnology company therefore
00:16:13involved our studies, one other thing that I think
00:16:17might be difficult is when you're looking around this
00:16:20laboratory uh there are scientists, there are engineers,
00:16:24there are clinicians, how do you
00:16:27coordinate everything, because
00:16:31not everything it's not a single discipline field, yeah
00:16:34yes definitely you are right, we build... here is
00:16:38very big ecosystems,
00:16:40you know one uh colleagues and also students come from the
00:16:44engineering part, but engineer part also has different
00:16:47departments, such as not only the
00:16:51meter science, bio engineering and bio and also mechanical
00:16:54engineering, we can also involve the computer engineering,
00:16:58this is the field the health, but we need the
00:17:02uh computer engineering also involved our studies, not only
00:17:06engineering part we... and also had to from the
00:17:09clinicians, from the uh medicine and
00:17:13also comes from the other disciplines,
00:17:17fundamental science, biology, chemical,
00:17:20chemistry and also physics as well,
00:17:24research, regulation, production, at some
00:17:28point all of this has to face the most important test of
00:17:32all, does it actually work a real patient? that's
00:17:35why we came here to chump secure a hospital in Istanbul
00:17:39where stem cell technology has moved out the lab and into
00:17:43daily clinical practice. This is one the places in
00:17:47Turkia's healthcare system where regenerative therapy is
00:17:51no longer just theoretical. It's a
00:17:54Wednesday afternoon, it's a scheduled procedure. It's
00:17:58a patient hoping for different outcome than the one
00:18:02conventional treatment offered to them. So, what is stem
00:18:05cell therapy actually offer?
00:18:11Before I was diagnosed with leukemia, I had no idea my treatment would be
00:18:15given through ivy drip. It turned out to be very simple
00:18:19process. Once I started treatment, I began to see how
00:18:23much the medication was affecting my body. I used to be very
00:18:27social person, but there were times when I had
00:18:29to be hospitalized. My life changed completely. After my
00:18:33stem so transplant, I realized how many things I had taken for.
00:18:38It made me truly appreciate the little things in
00:18:40life. It's not only the patients who
00:18:44benefit, for doctors, this technology represents something
00:18:48more than new tool in the kit. It's an expansion of what
00:18:52they're capable of treating, and of course how skills that used
00:18:56to stop at the limits of surgery now extend into the
00:18:59body's own regenerative capacity. Actually,
00:19:03we have two main sources for stem cells for ' this
00:19:07stem cell transplantation, firstly this
00:19:11is the peripherical stem cells and the second one is
00:19:15bonne marrow, bone marrow is great, yeah,
00:19:18and usually our
00:19:21patients need a peripheric stem cell source and
00:19:25we use mostly the peripherical stem cell source.
00:19:29think i have to ask you this question too, with the way things are
00:19:33advancing, take me five years down line, 10 years
00:19:37down. where are we in the medical industry when it comes to stem
00:19:40cells? i think that we have also so uh
00:19:43many new ways to obtain a cure for those
00:19:47patients. stem cell transplantation is very
00:19:51complicated process for our patients. we can also
00:19:55observe GVHD, prophers leukemia effects and and
00:19:59also some mortal adverse effects in stem cell transplantation.
00:20:03after stem cell transplant transplantation '
00:20:07and our patient had also grade 2-3
00:20:11GVHD after stump cell transplantation and it is so
00:20:14complicated to overcome this GVHD period and
00:20:18I think we have we will have new
00:20:21treatment methods in near
00:20:25future. Every stem cell treatment begins with
00:20:28collection, depending on the therapy, stem cells can be
00:20:32obtained from bone marrow, fat tissue or umbilical
00:20:36core blood and tissue after birth. once
00:20:40inside the laboratory, every sample undergoes extensive
00:20:43testing. scientists isolate the stem cells,
00:20:47verifying their quality and ensure the... meet strict safety
00:20:51standards before they can be used. some cells are
00:20:55prepared for immediate treatment, others are
00:20:58cryo-preserved and stored in liquid nitrogen at nearly
00:21:02minus 196° celsius, where they can remain
00:21:06viable for years. every sample is fully
00:21:10traceable throughout the entire process, from collection and
00:21:13storage to transportation and clinical use.
00:21:17every step is carefully documented and and monitored.
00:21:21when a patient needs treatment, the stem cells are retrieved,
00:21:25transported under carefully controlled conditions, and prepared for
00:21:29clinical use. it's the final step a process that can
00:21:32begin years before a patient ever walks into a
00:21:36hospital. what that graphic just walk
00:21:39through, collection, testing, storage at nearly minus
00:21:43200° celsius isn't a foot note. it's the
00:21:47entire infrastructure that makes everything. possible,
00:21:51long before a patient ever walks into a hospital, their
00:21:54treatment may already be years in the making, and by
00:21:58that I mean sitting quietly in liquid
00:22:01nitrogen, waiting. This is the world of
00:22:05biobanking, the not too glamorous, highly
00:22:08disciplined work of handling biological material so that it's
00:22:12ready exactly when it's needed. It's the world that
00:22:16Stembio operates in.
00:22:20Today we use stem cell therapies in many different areas, for
00:22:24example, we use them to stimulate and accelerate
00:22:27healing in chronic wounds, delayed fracture healing, or
00:22:31cases where healing is impaired. Both stem cell
00:22:35therapies themselves and stem-cell derived products such
00:22:38as exezomes are widely used for these
00:22:42purposes. What do they do? They enable communication
00:22:45between cells. When we administer exozomes from outside the body.
00:22:50Our goal is to restore that cellular communication and
00:22:54stimulate the body's natural healing processes once
00:22:56again. I think when you look at today, lot of people are
00:23:00talking about how much artificial intelligence is going to change
00:23:04our lives, and while some part of us that says, all right,
00:23:08it's going to improve our lives drastically, some part
00:23:11is fearful. Let ask you about regenerative
00:23:15medicine, take me five years down the line, where are we in five
00:23:19years? where regenerative medicine stands today already
00:23:22tells us something important: these therapies have
00:23:26demonstrated a strong safety profile. We now have
00:23:29approximately 25 to 30 years of accumulated data showing that
00:23:33these treatments can be administered safely and
00:23:36effectively. Moreover, many recent clinical
00:23:40studies have demonstrated meaningful clinical
00:23:43benefits. One the biggest expectations patients and the
00:23:47general public have is not simply living longer. but
00:23:50extending their healthy lifespan. For this reason,
00:23:54regenerative therapies are becoming increasingly popular in the field
00:23:58of longevity medicine. We are receiving interest and
00:24:01demand from all over the world. Anti-aging
00:24:05applications in particular have attracted tremendous
00:24:08attention. Discoveries like these have significantly
00:24:12expanded the possibilities for cellular therapies in healthy
00:24:16aging and age-related interventions. When these.
00:24:20supportive treatments are administered regularly and at appropriate
00:24:24intervals, they may contribute to healthier
00:24:26aging. one way to think about this is the state of
00:24:30chronic inflammation. the goal is to continuously control and
00:24:34slow down that
00:24:35process.
00:24:39as exciting as the science sounds, every researcher we've
00:24:43spoken to keeps returning to that same word:
00:24:46regulation, because the science can only move - fast
00:24:50as trust allows it to. the real challenge isn't
00:24:54discovering what is possible, it's actually preserving the
00:24:58integrity of that discovery long enough for it to last,
00:25:02earning trust, addressing legitimate fears and
00:25:06separating evidence from hype. that tension
00:25:10between possibility and caution is exactly where
00:25:13durmush
00:25:16is that? buradaki anahtar kelime aslında regulasyon.
00:25:20is regulation. In medicine, we're obliged to follow the
00:25:24principle of first do no harm. Cellular
00:25:27therapies, especially over the last 25 to 30 years,
00:25:31initially emerged as treatments aimed at replacing
00:25:35biological deficiencies. Today, however, they've evolved
00:25:39into therapies that can potentially support almost any tissue
00:25:42or organ in the body, either directly or
00:25:46indirectly. That said, there are areas where scientif.
00:25:50research and therapeutic applications overlap, well
00:25:54still remaining clearly distinct, this is where regulations
00:25:57become extremely important and in fact
00:26:01work to -
00:26:24Our organization manages multiple disciplines within biological medicine,
00:26:27both at the research level and at the clinical treatment
00:26:31level through and integrated operational
00:26:34framework, personalized medicine is very broad umbrella that
00:26:38encompasses biological therapies, including cellular
00:26:42therapies. the key question we ask is, is this individual
00:26:45a suitable candidate for this therapy? if so,
00:26:49which treatment protocol should be used, at what stage, and
00:26:53with which cellular therapy tool or approach? when we
00:26:57successfully bring all these components together, and when we look ahead,
00:27:005, 10 or 15. years into the future, we believe we'll
00:27:04see a strong upward trend in outcomes and
00:27:08adoption, and it's a trend that will all witness
00:27:11together.
00:27:16step back and what you start to see isn't a handful of separate
00:27:20companies, it's an entire ecosystem,
00:27:23advanced diagnostics decoding everything that could go
00:27:27wrong, and doing this a cellular level,
00:27:30healthcare across every link in that chain is becoming more
00:27:34precise, more individualized, less about a
00:27:38specific protocol, and more about a treatment built around
00:27:42one person's specific biology, and it's
00:27:45moving faster than most people realize, which
00:27:49leaves an open question, one that every scientist in the
00:27:53story circled back to in their own way: how do you make
00:27:56sure this technology is used ethically? how do you earn the
00:28:00public's trust without over? selling what still needs to be
00:28:04proven? those questions don't have a direct
00:28:07answer, at least not yet, but for the
00:28:11first time the people working on them have real tools
00:28:15and real evidence to work with. from
00:28:19storing cells for future use to scientists developing
00:28:22specific therapies to doctors using them on real
00:28:26patients. the fact the matter is that we're experiencing
00:28:29tectonic shift that medicine... isn't just about
00:28:33curing the disease, it's about regeneration,
00:28:37and the promises are powerful that the body can heal
00:28:41itself, that not all injuries require surgeries, and that
00:28:44healing is a very natural process, but like
00:28:48every frontier, the science needs to catch up with the
00:28:52ambition, and it will. well,
00:28:55that's it for this edition of nexttech from much younger and healthier
00:28:59feeling Adijana. thanks for watching. And we'll see you next
00:29:03time,
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00:29:28from the remotest reaches to the teaming
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00:29:35TRTworld.com.
00:29:40The Balkans is at the crossroads of history.
00:29:44Foreign influence has always weighed heavily on the
00:29:47people. The war in Ukraine
00:29:51has tested the fragile
00:29:53car.
00:29:58As global powers consider their next steps, few
00:30:01takento. consideration what the people here
00:30:04want
00:30:09across the balcans on TRT
00:30:12World.
00:30:28Jewish Americans are at the center the country's shifting views on.
00:30:34The Jewish people and the zionists are not the same. The state of Israel is
00:30:38here for a political movement to build support their
00:30:42nationalism. Benjamin Netanyahu is not welcome in New York
00:30:45City. So
00:30:49it's important to have like Jewish voices out there cuz unfortunately we live a
00:30:52very racist world where people listen to as a
00:30:56white Jewish man more than they will listen to a palestinan who's actually lost.